The Cyclomodulin Cycle Inhibiting Factor (CIF) Alters Cullin Neddylation Dynamics

The bacterial effector protein cycle inhibiting factor (CIF) converts glutamine 40 of NEDD8 to glutamate (Q40E), causing cytopathic effects and inhibiting cell proliferation. Although these have been attributed to blocking the functions of cullin-RING ubiquitin ligases, how CIF modulates NEDD8-depen...

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Bibliographic Details
Main Authors: Toro, Tasha B., Toth, Julia I., Petroski, Matthew D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663497/
https://ncbi.nlm.nih.gov/pubmed/23589306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.448258
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