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EMu: probabilistic inference of mutational processes and their localization in the cancer genome

The spectrum of mutations discovered in cancer genomes can be explained by the activity of a few elementary mutational processes. We present a novel probabilistic method, EMu, to infer the mutational signatures of these processes from a collection of sequenced tumors. EMu naturally incorporates the...

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Autors principals: Fischer, Andrej, Illingworth, Christopher JR, Campbell, Peter J, Mustonen, Ville
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663107/
https://ncbi.nlm.nih.gov/pubmed/23628380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2013-14-4-r39
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