IGF ACTIVATION IN A MOLECULAR SUBCLASS OF HEPATOCELLULAR CARCINOMA AND PRE-CLINICAL EFFICACY OF IGF-1R BLOCKAGE

BACKGROUND/AIMS: IGF signaling has a relevant role in a variety of human malignancies. We analyzed the underlying molecular mechanisms of IGF signaling activation in early hepatocellular carcinoma (HCC; BCLC class 0 or A) and assessed novel targeted therapies blocking this pathway METHODS: An integr...

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Autors principals: Tovar, Victoria, Alsinet, Clara, Villanueva, Augusto, Hoshida, Yujin, Chiang, Derek Y., Solé, Manel, Thung, Swan, Moyano, Susana, Toffanin, Sara, Mínguez, Beatriz, Cabellos, Laia, Peix, Judit, Schwartz, Myron, Mazzaferro, Vincenzo, Bruix, Jordi, Llovet, Josep M.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662876/
https://ncbi.nlm.nih.gov/pubmed/20206398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2010.01.015
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