Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib

PURPOSE: Hepatocellular carcinoma (HCC) is a heterogeneous cancer with active Wnt-signaling. Underlying biological mechanisms remain unclear and no drug targeting this pathway has been approved to date. We aimed to characterize Wnt-pathway aberrations in HCC patients, and to investigate sorafenib as...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lachenmayer, Anja, Alsinet, Clara, Savic, Radoslav, Cabellos, Laia, Toffanin, Sara, Hoshida, Yujin, Villanueva, Augusto, Minguez, Beatriz, Newell, Philippa, Tsai, Hung-Wen, Barretina, Jordi, Thung, Swan, Ward, Stephen C., Bruix, Jordi, Mazzaferro, Vincenzo, Schwartz, Myron, Friedman, Scott L., Llovet, Josep M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446854/
https://ncbi.nlm.nih.gov/pubmed/22811581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2322
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