BRCA1/2 Sequence Variants of Uncertain Significance: A Primer for Providers to Assist in Discussions and in Medical Management

INTRODUCTION. DNA variants of uncertain significance (VUS) are common outcomes of clinical genetic testing for susceptibility to cancer. A statistically rigorous model that provides a pathogenicity score for each variant has been developed to aid in the clinical management of patients undergoing gen...

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Hlavní autoři: Lindor, Noralane M., Goldgar, David E., Tavtigian, Sean V., Plon, Sharon E., Couch, Fergus J.
Médium: Artigo
Jazyk:Inglês
Vydáno: AlphaMed Press 2013
Témata:
Clinical Genetics and Genetic Counseling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662842/
https://ncbi.nlm.nih.gov/pubmed/23615697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2012-0452
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