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Upregulation of the mammalian X chromosome is associated with enhanced transcription initiation, MOF-mediated H4K16 acetylation, and longer RNA half-life

X upregulation in mammals increases levels of expressed X-linked transcripts to compensate for autosomal bi-allelic expression. Here, we present molecular mechanisms that enhance X expression at transcriptional and posttranscriptional levels. Active mouse X-linked promoters are enriched in the initi...

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書誌詳細
主要な著者: Deng, Xinxian, Berletch, Joel B., Ma, Wenxiu, Nguyen, Di Kim, Noble, William S., Shendure, Jay, Disteche, Christine M.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662796/
https://ncbi.nlm.nih.gov/pubmed/23523075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.01.028
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