Hydrogen Sulfide Donor NaHS Reduces Organ Injury in a Rat Model of Pneumococcal Pneumosepsis, Associated with Improved Bio-Energetic Status

Sepsis is characterized by a generalized inflammatory response and organ failure, associated with mitochondrial dysfunction. Hydrogen sulfide donor NaHS has anti-inflammatory properties, is able to reduce metabolism and can preserve mitochondrial morphology and function. Rats were challenged with li...

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Main Authors: Aslami, Hamid, Pulskens, Wilco P., Kuipers, Maria T., Bos, Aafkeline P., van Kuilenburg, André B. P., Wanders, Ronald J. A., Roelofsen, Jeroen, Roelofs, Joris J. T. H., Kerindongo, Raphaela P., Beurskens, Charlotte J. P., Schultz, Marcus J., Kulik, Wim, Weber, Nina C., Juffermans, Nicole P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662774/
https://ncbi.nlm.nih.gov/pubmed/23717435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063497
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