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How Ionic Strength Affects the Conformational Behavior of Human and Rat Beta Amyloids – A Computational Study

Progressive cerebral deposition of amyloid beta occurs in Alzheimeŕs disease and during the aging of certain mammals (human, monkey, dog, bear, cow, cat) but not others (rat, mouse). It is possibly due to different amino acid sequences at positions 5, 10 and 13. To address this issue, we performed s...

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Detalhes bibliográficos
Main Authors: Kříž, Zdeněk, Klusák, Jiří, Krištofíková, Zdena, Koča, Jaroslav
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662769/
https://ncbi.nlm.nih.gov/pubmed/23717395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062914
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