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How Ionic Strength Affects the Conformational Behavior of Human and Rat Beta Amyloids – A Computational Study

Progressive cerebral deposition of amyloid beta occurs in Alzheimeŕs disease and during the aging of certain mammals (human, monkey, dog, bear, cow, cat) but not others (rat, mouse). It is possibly due to different amino acid sequences at positions 5, 10 and 13. To address this issue, we performed s...

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Autori principali: Kříž, Zdeněk, Klusák, Jiří, Krištofíková, Zdena, Koča, Jaroslav
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662769/
https://ncbi.nlm.nih.gov/pubmed/23717395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062914
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