Microbial Translocation Is Associated with Extensive Immune Activation in Dengue Virus Infected Patients with Severe Disease

BACKGROUND: Severe dengue virus (DENV) disease is associated with extensive immune activation, characterized by a cytokine storm. Previously, elevated lipopolysaccharide (LPS) levels in dengue were found to correlate with clinical disease severity. In the present cross-sectional study we identified...

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Autors principals: van de Weg, Cornelia A. M., Pannuti, Cláudio S., de Araújo, Evaldo S. A., van den Ham, Henk-Jan, Andeweg, Arno C., Boas, Lucy S. V., Felix, Alvina C., Carvalho, Karina I., de Matos, Andreia M., Levi, José E., Romano, Camila M., Centrone, Cristiane C., de Lima Rodrigues, Celia L., Luna, Expedito, van Gorp, Eric C. M., Osterhaus, Albert D. M. E., Martina, Byron E. E., Kallas, Esper G.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662706/
https://ncbi.nlm.nih.gov/pubmed/23717702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002236
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