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Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells

We found that basal-like breast cancer (BLBC) cells use Cdc42 to inhibit function of the redox/Fyn/c-Cbl (RFC) pathway, which normally functions to convert small increases in oxidative status into enhanced degradation of c-Cbl target proteins. Restoration of RFC pathway function by genetic or pharma...

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Bibliografische gegevens
Hoofdauteurs: Chen, Hsing-Yu, Yang, Yin M, Stevens, Brett M, Noble, Mark
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: WILEY-VCH Verlag 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662315/
https://ncbi.nlm.nih.gov/pubmed/23606532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202140
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