APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study

Deposition of amyloid-β (Aβ) in the cerebral cortex is thought to be a pivotal event in Alzheimer’s disease (AD) pathogenesis with a significant genetic contribution. Molecular imaging can provide an early noninvasive phenotype but small samples have prohibited genome-wide association studies (GWAS)...

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Autors principals: Ramanan, Vijay K., Risacher, Shannon L., Nho, Kwangsik, Kim, Sungeun, Swaminathan, Shanker, Shen, Li, Foroud, Tatiana M., Hakonarson, Hakon, Huentelman, Matthew J., Aisen, Paul S., Petersen, Ronald C., Green, Robert C., Jack, Clifford R., Koeppe, Robert A., Jagust, William J., Weiner, Michael W., Saykin, Andrew J.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661739/
https://ncbi.nlm.nih.gov/pubmed/23419831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2013.19
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