PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablatio...

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Autores principales: He, Jinhan, Gao, Jie, Xu, Meishu, Ren, Songrong, Stefanovic-Racic, Maja, O'Doherty, Robert Martin, Xie, Wen
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2013
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661619/
https://ncbi.nlm.nih.gov/pubmed/23349477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1039
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