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PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice
The pregnane X receptor (PXR), along with its sister receptor constitutive androstane receptor (CAR), was initially characterized as a xenobiotic receptor that regulates drug metabolism. In this study, we have uncovered an unexpected endobiotic role of PXR in obesity and type 2 diabetes. PXR ablatio...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Diabetes Association
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3661619/ https://ncbi.nlm.nih.gov/pubmed/23349477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1039 |
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