Galectin-3 Deficiency Accelerates High-Fat Diet–Induced Obesity and Amplifies Inflammation in Adipose Tissue and Pancreatic Islets

Obesity-induced diabetes is associated with low-grade inflammation in adipose tissue and macrophage infiltration of islets. We show that ablation of galectin-3 (Gal-3), a galactoside-binding lectin, accelerates high-fat diet–induced obesity and diabetes. Obese LGALS3(−/−) mice have increased body we...

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Autori principali: Pejnovic, Nada N., Pantic, Jelena M., Jovanovic, Ivan P., Radosavljevic, Gordana D., Milovanovic, Marija Z., Nikolic, Ivana G., Zdravkovic, Nemanja S., Djukic, Aleksandar L., Arsenijevic, Nebojsa N., Lukic, Miodrag L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2013
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661611/
https://ncbi.nlm.nih.gov/pubmed/23349493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0222
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