Proinflammatory Cytokines and Bile Acids Upregulate ΔNp73 Protein, an Inhibitor of p53 and p73 Tumor Suppressors

Gastroesophageal reflux disease (GERD) is the main etiological factor behind the recent rapid increase in the incidence of esophageal adenocarcinoma. During reflux, esophageal cells are exposed to bile at low pH resulting in cellular damage and inflammation, which are known to facilitate cancer deve...

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Detalhes bibliográficos
Main Authors: Zaika, Elena, Bhardwaj, Vikas, Wei, Jinxiong, Washington, Mary Kay, Souza, Rhonda, El-Rifai, Wael, Zaika, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661465/
https://ncbi.nlm.nih.gov/pubmed/23717592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064306
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