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Detecting negative selection on recurrent mutations using gene genealogy

BACKGROUND: Whether or not a mutant allele in a population is under selection is an important issue in population genetics, and various neutrality tests have been invented so far to detect selection. However, detection of negative selection has been notoriously difficult, partly because negatively s...

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Bibliographic Details
Main Authors: Ezawa, Kiyoshi, Landan, Giddy, Graur, Dan
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661350/
https://ncbi.nlm.nih.gov/pubmed/23651527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-14-37
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