Pharmacokinetics of Stereoisomeric Dipeptide Prodrugs of Acyclovir Following Intravenous and Oral Administrations in Rats: A Study Involving In vivo Corneal Uptake of Acyclovir Following Oral Dosing

OBJECTIVE: To delineate the plasma pharmacokinetics and determine the corneal uptake of valine based stereoisomeric dipeptide prodrugs of acyclovir (ACV) in rats. METHODS: Male Sprague-Dawley rats were used for the study. Pharmacokinetics of ACV, L-valine-acyclovir (LACV), L-valine-D-valine-acyclovi...

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Autors principals: Talluri, Ravi S., Gaudana, Ripal, Hariharan, Sudharshan, Mitra, Ashim K.
Format: Artigo
Idioma:Inglês
Publicat: Libertas Academica 2009
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661318/
https://ncbi.nlm.nih.gov/pubmed/23861607
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