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Pharmacokinetics of amino acid ester prodrugs of Acyclovir after oral administration: Interaction with the transporters on Caco-2 cells

In vivo systemic absorption of the amino acid prodrugs of acyclovir (ACV) after oral administration was evaluated in rats. Stability of the prodrugs, L-Alanine-ACV (AACV), L-Serine-ACV (SACV), L-Isoleucine-ACV (IACV), γ-Glutamate-ACV (EACV) and L-Valine-ACV (VACV) was evaluated in various tissues. I...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Katragadda, Suresh, Jain, Ritesh, Kwatra, Deep, Hariharan, Sudharshan, Mitra, Ashim K.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2008
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830879/
https://ncbi.nlm.nih.gov/pubmed/18638532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2008.06.018
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