Inhibition of ARNT severely compromises endothelial cell viability and function in response to moderate hypoxia

Hypoxia Inducible Factor (HIF) is a master heterodimeric transcriptional regulator of oxygen (O(2)) homeostasis critical to proper angiogenic responses. Due to the distinctive coexpression of HIF-1α and HIF-2α subunits in endothelial cells, our goal was to examine the genetic elimination of HIF tran...

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Hlavní autoři: Han, Yu, Yang, Ke, Proweller, Aaron, Zhou, Guangjin, Jain, Mukesh K., Ramirez-Bergeron, Diana L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661274/
https://ncbi.nlm.nih.gov/pubmed/22484908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-012-9269-x
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