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Hypoxia influences the vascular expansion and differentiation of embryonic stem cell cultures through the temporal expression of VEGF- receptors in an ARNT-dependent manner
Adaptive responses to low oxygen (O(2)) tension (hypoxia) are mediated by the heterodimeric transcription factor Hypoxia Inducible Factor (HIF). When stabilized by hypoxia, bHLH-PAS α- and β-(HIF-1β or ARNT) HIF complex regulate the expression of multiple genes including vascular endothelial growth...
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| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2010
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2989499/ https://ncbi.nlm.nih.gov/pubmed/20135683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.316 |
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