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Inhibition of ARNT severely compromises endothelial cell viability and function in response to moderate hypoxia
Hypoxia Inducible Factor (HIF) is a master heterodimeric transcriptional regulator of oxygen (O(2)) homeostasis critical to proper angiogenic responses. Due to the distinctive coexpression of HIF-1α and HIF-2α subunits in endothelial cells, our goal was to examine the genetic elimination of HIF tran...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3661274/ https://ncbi.nlm.nih.gov/pubmed/22484908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-012-9269-x |
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