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Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment
Radiotherapy sensitizes unresponsive tumors to the antineoplastic activity of antibodies that target the inhibitory receptor CTLA-4 on T cells. One molecular mechanism accounting for this therapeutic synergy is the induction of NKG2D ligands on irradiated tumor cells. The fact that NKG2D receptors m...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3661148/ https://ncbi.nlm.nih.gov/pubmed/23802063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.23127 |
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