Accumulation of 2-hydroxyglutarate is not a biomarker for malignant progression in IDH-mutated low-grade gliomas

OBJECTIVES: To determine whether accumulation of 2-hydroxyglutarate in IDH-mutated low-grade gliomas (LGG; WHO grade II) correlates with their malignant transformation and to evaluate changes in metabolite levels during malignant progression. METHODS: Samples from 54 patients were screened for IDH m...

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Bibliographic Details
Main Authors: Juratli, Tareq A., Peitzsch, Mirko, Geiger, Kathrin, Schackert, Gabriele, Eisenhofer, Graeme, Krex, Dietmar
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661092/
https://ncbi.nlm.nih.gov/pubmed/23410661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not006
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