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A cell-penetrating peptide suppresses the hypoxia inducible factor-1 function by binding to the helix-loop-helix domain of the aryl hydrocarbon receptor nuclear translocator

The heterodimeric hypoxia inducible factor-1 (HIF-1) complex is composed of the hypoxia inducible factor-1 alpha (HIF-1α) and the aryl hydrocarbon receptor nuclear translocator (ARNT). Activation of the HIF-1 function is essential for tumor growth and metastasis. We previously showed that transfecti...

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Autori principali: Wang, Yu, Thompson, John D., Chan, William K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661001/
https://ncbi.nlm.nih.gov/pubmed/23454269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2013.02.003
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