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Suppression of the hypoxia inducible factor-1 function by redistributing the aryl hydrocarbon receptor nuclear translocator from nucleus to cytoplasm

The aryl hydrocarbon receptor nuclear translocator (ARNT) heterodimerizes with hypoxia inducible factor-1α (HIF-1α), followed by upregulation of genes that are essential for carcinogenesis. We utilized a novel peptide (Ainp1) to address whether the HIF-1α signaling could be suppressed by an ARNT-med...

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Hlavní autoři: Wang, Yu, Li, Yanjie, Wang, Depeng, Li, Yi, Chang, Abraham, Chan, William K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319868/
https://ncbi.nlm.nih.gov/pubmed/22306343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2012.01.037
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