Protein O-GlcNAcylation Is Required for Fibroblast Growth Factor Signaling in Drosophila

Glycosylation is essential for growth factor signaling through N-glycosylation of ligands and receptors and the biosynthesis of proteoglycans as co-receptors. Here, we show that protein O-GlcNAcylation is crucial for fibroblast growth factor (FGF) signaling in Drosophila. We found that nesthocker (n...

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Библиографические подробности
Главные авторы: Mariappa, Daniel, Sauert, Kathrin, Mariño, Karina, Turnock, Daniel, Webster, Ryan, van Aalten, Daan M. F., Ferguson, Michael A. J., Müller, H.-Arno J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660836/
https://ncbi.nlm.nih.gov/pubmed/22375049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002335
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