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Competitive but Not Allosteric mTOR Kinase Inhibition Enhances Tumor Cell Radiosensitivity

The mechanistic target of rapamycin (mTOR) is a critical kinase in the regulation of gene translation and has been suggested as a potential target for radiosensitization. The goal of this study was to compare the radiosensitizing activities of the allosteric mTOR inhibitor rapamycin with that of the...

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Bibliographic Details
Main Authors: Hayman, Thomas J, Kramp, Tamalee, Kahn, Jenna, Jamal, Muhammad, Camphausen, Kevin, Tofilon, Philip J
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660805/
https://ncbi.nlm.nih.gov/pubmed/23730416
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