TLR3 activation evokes IL-6 secretion, autocrine regulation of Stat3 signaling and TLR2 expression in human bronchial epithelial cells

Human bronchial epithelial cells exposed to synthetic double-stranded RNA (poly I:C) exhibited increased IL-6 and RANTES secretion and TLR2 expression that was inhibited following TLR3 silencing. Increased NF-κB and Stat3 phosphorylation were detected after poly I:C exposure and pretreatment with ne...

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Detaylı Bibliyografya
Asıl Yazarlar: Melkamu, Tamene, Kita, Hirohito, O’Grady, Scott M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Netherlands 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660690/
https://ncbi.nlm.nih.gov/pubmed/23232980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-012-0185-z
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