Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling

The hormone relaxin (RLX) is produced by the heart and has beneficial actions on the cardiovascular system. We previously demonstrated that RLX stimulates mouse neonatal cardiomyocyte growth, suggesting its involvement in endogenous mechanisms of myocardial histogenesis and regeneration. In the pres...

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Detalhes bibliográficos
Main Authors: Sassoli, Chiara, Chellini, Flaminia, Pini, Alessandro, Tani, Alessia, Nistri, Silvia, Nosi, Daniele, Zecchi-Orlandini, Sandra, Bani, Daniele, Formigli, Lucia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660557/
https://ncbi.nlm.nih.gov/pubmed/23704950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063896
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