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Relaxin Prevents Cardiac Fibroblast-Myofibroblast Transition via Notch-1-Mediated Inhibition of TGF-β/Smad3 Signaling

The hormone relaxin (RLX) is produced by the heart and has beneficial actions on the cardiovascular system. We previously demonstrated that RLX stimulates mouse neonatal cardiomyocyte growth, suggesting its involvement in endogenous mechanisms of myocardial histogenesis and regeneration. In the pres...

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書誌詳細
主要な著者: Sassoli, Chiara, Chellini, Flaminia, Pini, Alessandro, Tani, Alessia, Nistri, Silvia, Nosi, Daniele, Zecchi-Orlandini, Sandra, Bani, Daniele, Formigli, Lucia
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660557/
https://ncbi.nlm.nih.gov/pubmed/23704950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063896
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