Regorafenib in combination with FOLFOX or FOLFIRI as first- or second-line treatment of colorectal cancer: results of a multicenter, phase Ib study

BACKGROUND: Metastatic colorectal cancer (mCRC) is commonly treated with 5-fluorouracil, folinic acid, and oxaliplatin or irinotecan. The multitargeted kinase inhibitor, regorafenib, was combined with chemotherapy as first- or second-line treatment of mCRC to assess safety and pharmacokinetics (prim...

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Main Authors: Schultheis, B., Folprecht, G., Kuhlmann, J., Ehrenberg, R., Hacker, U. T., Köhne, C. H., Kornacker, M., Boix, O., Lettieri, J., Krauss, J., Fischer, R., Hamann, S., Strumberg, D., Mross, K. B.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660081/
https://ncbi.nlm.nih.gov/pubmed/23493136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdt056
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