Constant activation of the RAF-MEK-ERK pathway as a diagnostic and therapeutic target in hairy cell leukemia

The BRAF-V600E mutation defines genetically hairy cell leukemia among B-cell leukemias and lymphomas. In solid tumors, BRAF-V600E is known to aberrantly activate the oncogenic MEK-ERK pathway, and targeted BRAF and/or MEK inhibitors have shown remarkable efficacy in clinical trials in melanoma patie...

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Hlavní autoři: Tiacci, Enrico, Schiavoni, Gianluca, Martelli, Maria Paola, Boveri, Emanuela, Pacini, Roberta, Tabarrini, Alessia, Zibellini, Silvia, Santi, Alessia, Pettirossi, Valentina, Fortini, Elisabetta, Ascani, Stefano, Arcaini, Luca, Inghirami, Giorgio, Paulli, Marco, Falini, Brunangelo
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2013
Témata:
Original Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659996/
https://ncbi.nlm.nih.gov/pubmed/23349307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.078071
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