Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27

CD27, a tumor necrosis factor receptor family member, interacts with CD70 and influences T-, B- and NK-cell functions. Disturbance of this axis impairs immunity and memory generation against viruses including Epstein Barr virus (EBV), influenza, and others. CD27 is commonly used as marker of memory...

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Hauptverfasser: Salzer, Elisabeth, Daschkey, Svenja, Choo, Sharon, Gombert, Michael, Santos-Valente, Elisangela, Ginzel, Sebastian, Schwendinger, Martina, Haas, Oskar A., Fritsch, Gerhard, Pickl, Winfried F., Förster-Waldl, Elisabeth, Borkhardt, Arndt, Boztug, Kaan, Bienemann, Kirsten, Seidel, Markus G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659923/
https://ncbi.nlm.nih.gov/pubmed/22801960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.068791
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