Efficient Lentiviral Transduction of Human Mesenchymal Stem Cells That Preserves Proliferation and Differentiation Capabilities

Long-term lentiviral transduction of human mesenchymal stem cells (hMSCs) greatly enhances the usefulness of these cells. However, such transduction currently requires the use of polybrene, which severely inhibits hMSC proliferation. In contrast, protamine sulfate at 100 μg/ml doubled transduction e...

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Detalhes bibliográficos
Main Authors: Lin, Paul, Lin, Yuan, Lennon, Donald P., Correa, Diego, Schluchter, Mark, Caplan, Arnold I.
Formato: Artigo
Idioma:Inglês
Publicado em: AlphaMed Press 2012
Assuntos:
Enabling Technologies for Cell-Based Clinical Translation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659678/
https://ncbi.nlm.nih.gov/pubmed/23283550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2012-0086
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