The transcobalamin receptor knockout mouse: a model for vitamin B(12) deficiency in the central nervous system

The membrane receptor (TCblR/CD320) for transcobalamin (TC)-bound cobalamin (Cbl) facilitates the cellular uptake of Cbl. A genetically modified mouse model involving ablation of the CD320 gene was generated to study the effects on cobalamin homeostasis. The nonlethal nature of this knockout and the...

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Hlavní autoři: Lai, Shao-Chiang, Nakayama, Yasumi, Sequeira, Jeffrey M., Wlodarczyk, Bogdan J., Cabrera, Robert M., Finnell, Richard H., Bottiglieri, Teodoro, Quadros, Edward V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2013
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659357/
https://ncbi.nlm.nih.gov/pubmed/23430977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-219055
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