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Vitamin B(12) deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse
BACKGROUND: DNA methylation is an epigenetic phenomenon that can modulate gene function by up or downregulation of gene expression. Vitamin B(12) and folate pathways are involved in the production of S-Adenosylmethionine, the universal methyl donor. FINDINGS: Brain vitamin B(12) concentration and gl...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3433370/ https://ncbi.nlm.nih.gov/pubmed/22607050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-7075-9-41 |
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