Vitamin B(12) deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse

BACKGROUND: DNA methylation is an epigenetic phenomenon that can modulate gene function by up or downregulation of gene expression. Vitamin B(12) and folate pathways are involved in the production of S-Adenosylmethionine, the universal methyl donor. FINDINGS: Brain vitamin B(12) concentration and gl...

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Detaylı Bibliyografya
Asıl Yazarlar: Fernàndez-Roig, Sílvia, Lai, Shao-Chiang, Murphy, Michelle M, Fernandez-Ballart, Joan, Quadros, Edward V
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2012
Konular:
Brief Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433370/
https://ncbi.nlm.nih.gov/pubmed/22607050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-7075-9-41
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