Hematopoietic Sphingosine 1-Phosphate Lyase Deficiency Decreases Atherosclerotic Lesion Development in LDL-Receptor Deficient Mice

AIMS: Altered sphingosine 1-phosphate (S1P) homeostasis and signaling is implicated in various inflammatory diseases including atherosclerosis. As S1P levels are tightly controlled by S1P lyase, we investigated the impact of hematopoietic S1P lyase (Sgpl1(−/−)) deficiency on leukocyte subsets releva...

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Bibliografiska uppgifter
Huvudupphovsmän: Bot, Martine, Van Veldhoven, Paul P., de Jager, Saskia C. A., Johnson, Jason, Nijstad, Niels, Van Santbrink, Peter J., Westra, Marijke M., Van Der Hoeven, Gerd, Gijbels, Marion J., Müller-Tidow, Carsten, Varga, Georg, Tietge, Uwe J. F., Kuiper, Johan, Van Berkel, Theo J. C., Nofer, Jerzy-Roch, Bot, Ilze, Biessen, Erik A. L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659045/
https://ncbi.nlm.nih.gov/pubmed/23700419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063360
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