Hematopoietic Sphingosine 1-Phosphate Lyase Deficiency Decreases Atherosclerotic Lesion Development in LDL-Receptor Deficient Mice

AIMS: Altered sphingosine 1-phosphate (S1P) homeostasis and signaling is implicated in various inflammatory diseases including atherosclerosis. As S1P levels are tightly controlled by S1P lyase, we investigated the impact of hematopoietic S1P lyase (Sgpl1(−/−)) deficiency on leukocyte subsets releva...

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Main Authors: Bot, Martine, Van Veldhoven, Paul P., de Jager, Saskia C. A., Johnson, Jason, Nijstad, Niels, Van Santbrink, Peter J., Westra, Marijke M., Van Der Hoeven, Gerd, Gijbels, Marion J., Müller-Tidow, Carsten, Varga, Georg, Tietge, Uwe J. F., Kuiper, Johan, Van Berkel, Theo J. C., Nofer, Jerzy-Roch, Bot, Ilze, Biessen, Erik A. L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659045/
https://ncbi.nlm.nih.gov/pubmed/23700419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063360
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