Clinical Adjuvant Combinations Stimulate Potent B-Cell Responses In Vitro by Activating Dermal Dendritic Cells

CD14(+) dermal DCs (CD14(+) DDCs) have a natural capacity to activate naïve B-cells. Targeting CD14(+) DDCs is therefore a rational approach for vaccination strategies aimed at improving humoral responses towards poorly immunogenic antigens, for example, HIV-1 envelope glycoproteins (Env). Here, we...

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Autors principals: Matthews, Katie, Chung, Nancy P. Y., Klasse, Per Johan, Moutaftsi, Magda, Carter, Darrick, Salazar, André M., Reed, Steven G., Sanders, Rogier W., Moore, John P.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659025/
https://ncbi.nlm.nih.gov/pubmed/23700434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063785
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