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Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells
Centrosome amplification plays a key role in the origin of chromosomal instability (CIN) during cancer development and progression. In this study, MCF-7 breast cancer cell lines harboring abrogated p53 function (vMCF-7(DNp53)) were employed to investigate the relationship between induction of genoto...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
D.A. Spandidos
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3658847/ https://ncbi.nlm.nih.gov/pubmed/23446853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2013.2313 |
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