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A valid formulation of the analysis of noninferiority trials under random effects meta-analysis

A noninferiority (NI) trial is sometimes employed to show efficacy of a new treatment when it is unethical to randomize current patients to placebo because of the established efficacy of a standard treatment. Under this framework, if the NI trial determines that the treatment advantage of the standa...

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Detalles Bibliográficos
Main Authors: Brittain, Erica H., Fay, Michael P., Follmann, Dean A.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658490/
https://ncbi.nlm.nih.gov/pubmed/22467938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxs006
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