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A Single Mutant, A276S of p53 Turns the Switch to Apoptosis

The tumor suppressor protein p53 induces apoptosis, cell cycle arrest, and DNA repair along with other functions in a transcription-dependent manner(1). The selection of these functions depends on sequence-specific recognition of p53 to a target decameric sequence of gene promoters(2). Amino acid re...

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Main Authors: Reaz, Shams, Mossalam, Mohanad, Okal, Abood, Lim, Carol. S.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658472/
https://ncbi.nlm.nih.gov/pubmed/23402381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300598k
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