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Controlled Access of p53 to the Nucleus Regulates its Proteasomal Degradation by MDM2
The tumor suppressor p53 can be sent to the proteasome for degradation by placing its nucleo-cytoplasmic shuttling under ligand control. Endogenous p53 is ubiquitinated by MDM2 in the nucleus, and controlling the access of p53 to the nuclear compartment regulates its ubiquitination and proteasomal d...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3658471/ https://ncbi.nlm.nih.gov/pubmed/23398638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp300543t |
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