NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Non-canonical NF-κB Signaling and MAP Kinase Activation

In vitro data suggest that a subgroup of NLR proteins, including NLRP12, inhibits the transcription factor NF-κB, although physiologic and disease-relevant evidence is largely missing. Dysregulated NF-κB activity is associated with colonic inflammation and cancer, and we found Nlrp12(-/-) mice were...

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Bibliographic Details
Main Authors: Allen, Irving C., Wilson, Justin E., Schneider, Monika, Lich, John D., Roberts, Reid A., Arthur, Janelle C., Woodford, Rita-Marie T., Davis, Beckley K., Uronis, Joshua M., Herfarth, Hans H., Jobin, Christian, Rogers, Arlin B., Ting, Jenny P.-Y.
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658309/
https://ncbi.nlm.nih.gov/pubmed/22503542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.03.012
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