Tardbpl splicing rescues motor neuron and axonal development in a mutant tardbp zebrafish

Mutations in the transactive response DNA binding protein-43 (TARDBP/TDP-43) gene, which regulates transcription and splicing, causes a familial form of amyotrophic lateral sclerosis (ALS). Here, we characterize and report the first tardbp mutation in zebrafish, which introduces a premature stop cod...

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Detalhes bibliográficos
Main Authors: Hewamadduma, Channa A.A., Grierson, Andrew J., Ma, Taylur P., Pan, Luyuan, Moens, Cecilia B., Ingham, Philip W., Ramesh, Tennore, Shaw, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658164/
https://ncbi.nlm.nih.gov/pubmed/23427147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt082
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