Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

Mast cells are known effector cells in allergic and inflammatory diseases, but their precise roles in intestinal inflammation remain unknown. Here we show that activation of mast cells in intestinal inflammation is mediated by ATP-reactive P2X7 purinoceptors. We find an increase in the numbers of ma...

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Autors principals: Kurashima, Yosuke, Amiya, Takeaki, Nochi, Tomonori, Fujisawa, Kumiko, Haraguchi, Takeshi, Iba, Hideo, Tsutsui, Hiroko, Sato, Shintaro, Nakajima, Sachiko, Iijima, Hideki, Kubo, Masato, Kunisawa, Jun, Kiyono, Hiroshi
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3658010/
https://ncbi.nlm.nih.gov/pubmed/22948816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2023
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