EFFECTS OF ESTROGEN AND AGING ON THE SYNAPTIC DISTRIBUTION OF PHOSPHORYLATED AKT-IMMUNOREACTIVITY IN THE CA1 REGION OF THE FEMALE RAT HIPPOCAMPUS

The estrogen 17β-estradiol (E) increases the axospinous synaptic density and plasticity in the hippocampal CA1 region of young female rats but fails to do so in aged female rats. This E stimulus on synaptic plasticity is associated with the phosphorylation-dependent activation of Akt kinase. Our pre...

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Huvudupphovsmän: Yildirim, Murat, Janssen, William G.M., Lou, W.Y. Wendy, Akama, Keith T., McEwen, Bruce S., Milner, Teresa A., Morrison, John H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657736/
https://ncbi.nlm.nih.gov/pubmed/20709039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2010.07.053
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