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Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors

To address the role of D1 receptors in the medial prefrontal cortex, we combined pharmacological and genetic manipulations to examine long-term synaptic potentiation (LTP)/long-term synaptic depression (LTD) in brain slices of rats and mice. We found that the D1 antagonist SCH23390 selectively block...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Huang, Yan-You, Simpson, Eleanor, Kellendonk, Christoph, Kandel, Eric R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365773/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14981263/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308280101
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