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Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR
Most of our understanding of G protein–coupled receptor (GPCR) activation has been focused on the direct interaction between diffusible ligands and their seven-transmembrane domains. However, a number of these receptors depend on their extracellular N-terminal domain for ligand recognition and activ...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3657613/ https://ncbi.nlm.nih.gov/pubmed/22729149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1008 |
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